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KMID : 0043319940170010017
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Archives of Pharmacal Research
1994 Volume.17 No. 1 p.17 ~ p.20
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Synthesis of 2-(2-Fluorenyl)propanoic Acid
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Choi Hong-Dae
Geum Dek-Hyun
Kowak Yong-Sil
Son Byeng-Wha
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Abstract
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Friedel-Crafts reaction of fluorene with methyl -chloro--(methylthio)acetate 1 gave methyl -methylthio-2-fluoreneacetate 2. Cicloprofen 8, a potent antiinflammatory agent, was prepared by methylation of 2 followed by reductive desulfurization of methyl 2(2-fluorenyl)-2-(methylthio)propionate 6 and hydrolysis of methyl 2-(2-fluorenyl)propionate 7.
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KEYWORD
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Friedel-Crafts reaciton, Fluorene, Methy ${\alpha}$-chloro-α-(methylthio)acetate, Cicloprofen, Antiinflammatory agent, Methylation, Reductive desulfurization, Hydrolysis
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